The initiative of the three Amsterdam-based hospitals stems from a broader collaboration with the University of Amsterdam, Vrije Universiteit Amsterdam, the City of Amsterdam, Amsterdam Economic Board and Philips. Furthermore, the hospitals are working closely with Amsterdam AI, the Amsterdam collaboration on artificial intelligence, and Health-RI, which is committed to a nationwide integrated health data infrastructure for research, policy and innovation.

With better and faster exchange of healthcare data, HDSA facilitates scientific research into health, better medical insight into how people can stay healthy for a long time, personalized prevention, treatment of diseases and quality of care. The HDSA collaboration is a first step in connecting to (a yet to be built) national infrastructure derived from the Integral Care Agreement (IZA) and a European collaboration via the European Health Data Space (EHDS).